Valencia missed out on an opportunity to regain second spot after losing 3-0 at Deportivo La Coruña on Sunday.
An own goal from José Gayá set the wheels in motion and two more from Lucas Perez and Toché sealed it for the hosts.
It is Sevilla who take over second place in La Liga after a 0-2 win at Elche, Bacca and Gameiro scoring in the second half of the match.