The world’s most expensive player, like his predecessor and team-mate, scored on his debut for Real Madrid, although it took Gareth Bale three minutes longer to find the net than was the case with Cristiano Ronaldo.
Cani gave Villarreal an early lead before Bale, who had a quiet start to the game, burst into life and found the net in the 38th minute. Ronaldo then scored his 203rd goal in 203 games only to see Dos Santos level matters once more in the 70th minute.
The final score was 2-2 and it was the first dropped points for both teams. Only Atlético and Barcelona remain with 100% records.
Alves, Messi and Alexis were on target for Barcelona as they edged Sevilla 3-2 on Saturday evening, Rakitic and Coke the scorers for the visitors.
Villa, Diego Costa, Tiago and Koke helped Atlético Madrid to a 4-2 win against Almeria and they now top La Liga after four matches. Rodri and Vidal were the scorers for Almeria.