An own goal from Miranda and strikes from André Gomes and Otamendi saw Valencia go three-up against Atlético Madrid within the first 13 minutes of their game on Sunday.
Mandzukic pulled one back for the visitors but it wasn’t enough and Valencia stay second in La Liga, two points behind leaders Barcelona.
Sevilla are up to third in La Liga after a comfortable 4-1 win over Deportivo La Coruña, with goals from Mbia (2), Bacca and Vitola. Medunjanin was the scorer for Deportivo.