Atlético Madrid slipped up on Sunday, beaten 2-0 by Celta de Vigo, and are now seven points adrift of their city rivals.
An Agudo Duran penalty in the 51st minute put the home side ahead and Orellana added a second to give Celta a somewhat surprising, but deserved win.
Villarreal stay comfortably sixth in La Liga despite losing 2-0 to Rayo Vallecano, Bueno and Gaël Kakuta scoring the goals in the second half.