Europa League and Sevilla topped Group H after a 0-2 win at SC Freiburg, goals from Iborra and Rusescu.
Valencia, already top of Group A, drew 1-1 with Kuban Krasdodar and progress to the next round. Alcácer put Valencia ahead before Melgarejo equalised with six minutes of the match remaining.
Real Betis finished second in Group I after a 0-0 draw with NK Rijeka.