A 1-0 victory on the night and 3-1 on aggregate saw Barcelona reach the quarter-finals of the Champions League.
Real Madrid qualified for their fifth successive Champions League quarter-final on Tuesday, but only just.
Luis Suarez scored twice as Barcelona beat Manchester City 1-2 in their Champions League last-16 first leg encounter on Tuesday night.
A headed goal from Ronaldo and a right-footed(!) strike from Marcelo saw Real Madrid beat Schalke 04 to give them the advantage for the second leg.
Neymar, Messi and Suarez scored as Barcelona beat Paris St-Germain 3-1 to secure top spot in Group F of the Champions League.
Ronaldo from the penalty spot, Bale, Arbeloa and Medrán helped Real Madrid to a 4-0 win over Ludogorets Razgrad in the Champions League, making it six wins out of six.
One from Raúl Garcia and a hat-trick from Mandzukic gave Atlético a very comfortable 4-0 against Olympiakos and they remain top of Group A with 12 points from 5 matches.
Another record for the master as Lionel Messi becomes the Champions League all-time top scorer with a hat-trick against Apoel Nicosia.
Two goals from Lionel Messi saw Barcelona ease past Axax 0-2 in the Champions League and they sit in second place in Group F on 9 points, one behind Paris Saint-Germain.
Real Madrid dominated their match against Liverpool in the Champions League but could only manage one goal, that coming from Benzema in the 27th minute.